Use of aqueous extracts of Giloy Ghanvati (Tinospora cordifolia) for treatment of (SARS-CoV-2)

Research Published Date: 19 April 2021

Research by : Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India


In the current study, researchers have used a humanized zebrafish model for determining the effect of Giloy Ghanvati in reversing the inflammation, and tissue damage caused by the induction of SARS-CoV-2 spike protein.

Zebrafish (Danio rerio) has been a reliable model for infectious diseases and studying the immune function in response to the introduction of human viruses

The study demonstrate the pro-inflammatory changes and tissue damage induced by SARS-CoV-2 spike-protein induction in the zebrafish and show the rescue of the disease pathology upon treatment with Giloy Ghanvati through morphological examination of the swim bladder and kidney, quantitate the immune cell infiltration through cytology, and finally show the restoration of behavioral fever and mortality induced by the spike protein.

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